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In this post you can download notes of Medicinal Chemistry 2 (BP501T). All units are available to download for free.
Medicinal Chemistry 2 Notes Unit 1 – 5
UNIT – 1
Antihistaminic agents, H1–antagonists, H2-antagonists, Gastric Proton pump inhibitors, Anti-neoplastic agents, Alkylating agents, Antimetabolites, Antibiotics, Plant products, Miscellaneous
UNIT – 2
Anti-anginal, Vasodilators, Calcium channel blockers, Diuretics, Anti-hypertensive Agents
UNIT – 3
Anti-arrhythmic Drugs, Anti-hyperlipidemic agents, Coagulants and Anticoagulants, Drugs used in Congestive Heart Failure
UNIT – 4
Drugs acting on Endocrine, Sex hormones, Drugs for erectile dysfunction, Oral contraceptives, Thyroid and antithyroid, Corticosteroids
UNIT – 5
Antidiabetic agents, Local Anesthetics, Benzoic Acid derivatives, Amino Benzoic acid derivatives, Lidocaine/Anilide derivatives, Miscellaneous
Syllabus of Medicinal Chemistry 2
UNIT – 1
Antihistaminic agents: Histamine, receptors and their distribution in the
humanbody
H1–antagonists: Diphenhydramine hydrochloride, Dimenhydrinate, Doxylamines cuccinate, Clemastine fumarate, Diphenylphyraline hydrochloride, Tripelenamine hydrochloride, Chlorcyclizine hydrochloride, Meclizine hydrochloride, Buclizine hydrochloride, Chlorpheniramine maleate, Triprolidine hydrochloride, Phenidamine tartarate, Promethazine hydrochloride, Trimeprazine tartrate, Cyproheptadine hydrochloride, Azatidine maleate, Astemizole, Loratadine, Cetirizine, Levocetrazine Cromolyn sodium
H2-antagonists: Cimetidine, Famotidine, Ranitidin.
Gastric Proton pump inhibitors: Omeprazole, Lansoprazole, Rabeprazole,
Pantoprazole
Anti-neoplastic agents:
Alkylating agents: Meclorethamine*, Cyclophosphamide, Melphalan, Chlorambucil, Busulfan, Thiotepa
Antimetabolites: Mercaptopurine, Thioguanine, Fluorouracil, Floxuridine, Cytarabine, Methotrexate, Azathioprine
Antibiotics: Dactinomycin, Daunorubicin, Doxorubicin, Bleomycin
Plant products: Etoposide, Vinblastin sulphate, Vincristin sulphate
Miscellaneous: Cisplatin, Mitotane.
UNIT – 2
Anti-anginal:
Vasodilators: Amyl nitrite, Nitroglycerin, Pentaerythritol tetranitrate, Isosorbide dinitrite, Dipyridamole.
Calcium channel blockers: Verapamil, Bepridil hydrochloride, Diltiazem
hydrochloride, Nifedipine, Amlodipine, Felodipine, Nicardipine, Nimodipine.
Diuretics:
Carbonic anhydrase inhibitors: Acetazolamide, Methazolamide, Dichlorphenamide.
Thiazides: Chlorthiazide, Hydrochlorothiazide, Hydroflumethiazide,
Cyclothiazide,
Loop diuretics: Furosemide, Bumetanide, Ethacrynic acid.
Potassium sparing Diuretics: Spironolactone, Triamterene, Amiloride.
Osmotic Diuretics: Mannitol
Anti-hypertensive Agents: Timolol, Captopril, Lisinopril, Enalapril, Benazepril hydrochloride, Quinapril hydrochloride, Methyldopate hydrochloride, Clonidine
hydrochloride, Guanethidine monosulphate, Guanabenz acetate, Sodium
nitroprusside, Diazoxide, Minoxidil, Reserpine, Hydralazine hydrochloride
UNIT – 3
Anti-arrhythmic Drugs: Quinidine sulphate, Procainamide hydrochloride, Disopyramide phosphate, Phenytoin sodium, Lidocaine hydrochloride, Tocainide hydrochloride, Mexiletine hydrochloride, Lorcainide hydrochloride, Amiodarone, Sotalol.
Anti-hyperlipidemic agents: Clofibrate, Lovastatin, Cholesteramine and Cholestipol
Coagulant & Anticoagulants: Menadione, Acetomenadione, Warfarin,
Anisindione, clopidogrel
Drugs used in Congestive Heart Failure: Digoxin, Digitoxin, Nesiritide,
Bosentan, Tezosentan.
UNIT – 4
Drugs acting on Endocrine system
Nomenclature, Stereochemistry and metabolism of steroids
Sex hormones: Testosterone, Nandralone, Progestrones, Oestriol, Oestradiol,
Oestrione, Diethyl stilbestrol.
Drugs for erectile dysfunction: Sildenafil, Tadalafil.
Oral contraceptives: Mifepristone, Norgestril, Levonorgestrol
Corticosteroids: Cortisone, Hydrocortisone, Prednisolone, Betamethasone,
Dexamethasone
Thyroid and antithyroid drugs: L-Thyroxine, L-Thyronine, Propylthiouracil,
Methimazole.
UNIT – 5
Antidiabetic agents:
Insulin and its preparations
Sulfonyl ureas: Tolbutamide, Chlorpropamide, Glipizide, Glimepiride. Biguanides: Metformin.
Thiazolidinediones: Pioglitazone, Rosiglitazone.
Meglitinides: Repaglinide, Nateglinide.
Glucosidase inhibitors: Acrabose, Voglibose.
Local Anesthetics: SAR of Local anesthetics
Benzoic Acid derivatives; Cocaine, Hexylcaine, Meprylcaine, Cyclomethycaine, Piperocaine.
Amino Benzoic acid derivatives: Benzocaine, Butamben, Procaine*, Butacaine, Propoxycaine, Tetracaine, Benoxinate.
Lidocaine/Anilide derivatives: Lignocaine, Mepivacaine, Prilocaine, Etidocaine.
Miscellaneous: Phenacaine, Diperodon, Dibucaine.
Scope of Medicinal Chemistry 2
This subject is designed to impart fundamental knowledge on the structure, chemistry and therapeutic value of drugs.
The subject emphasizes on structure activity relationships of drugs, importance of physicochemical properties and metabolism of drugs.
The syllabus also emphasizes on chemical synthesis of important drugs under each class.
Objectives of Medicinal Chemistry 2
Upon completion of the course the student shall be able to:
- Understand the chemistry of drugs with respect to their pharmacological activity
- Understand the drug metabolic pathways, adverse effect and therapeutic value of
drugs - Know the Structural Activity Relationship of different class of drugs
- Study the chemical synthesis of selected drugs
Course Content