Download High-quality and well-structured notes of “Pharmaceutical Chemistry” in pdf – Dpharm 1st Year – STANDARD NOTES.
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Pharmaceutical Chemistry Notes
CHAPTER 1
Introduction to Pharmaceutical chemistry: Scope and objectives
Sources and types of errors: Accuracy, precision, significant figures
Impurities in Pharmaceuticals: Source and effect of impurities in Pharmacopoeial substances, importance of limit test, Principle and procedures of Limit tests for chlorides, sulphates, iron, heavy metals and arsenic.
CHAPTER 2
Volumetric analysis: Fundamentals of volumetric analysis, Acid-base titration, non-aqueous titration,
precipitation titration, complexometric titration, redox titration
Gravimetric analysis: Principle and method.
CHAPTER 3
Inorganic Pharmaceuticals: Pharmaceutical formulations, market preparations, storage conditions and uses of
● Haematinics: Ferrous sulphate, Ferrous fumarate, Ferric ammonium citrate, Ferrous ascorbate, Carbonyl iron
● Gastro-intestinal Agents: Antacids :Aluminium hydroxide gel, Magnesium hydroxide, Magaldrate,
Sodium bicarbonate, Calcium Carbonate, Acidifying agents, Adsorbents, Protectives, Cathartics
● Topical agents: Silver Nitrate, Ionic Silver, Chlorhexidine Gluconate, Hydrogen peroxide, Boric
acid, Bleaching powder, Potassium permanganate
● Dental products: Calcium carbonate, Sodium
fluoride, Denture cleaners, Denture adhesives, Mouth washes
● Medicinal gases: Carbon dioxide, nitrous oxide,
oxygen
CHAPTER 4
Introduction to nomenclature of organic chemical systems with particular reference to heterocyclic compounds containing up to Three rings
CHAPTER 5
Drugs Acting on Central Nervous System
● Anaesthetics: Thiopental Sodium, Ketamine Hydrochloride, Propofol
● Sedatives and Hypnotics: Diazepam, Alprazolam, Nitrazepam, Phenobarbital*
● Antipsychotics: Chlorpromazine Hydrochloride, Haloperidol, Risperidone, Sulpiride, Olanzapine,
Quetiapine, Lurasidone
● Anticonvulsants: Phenytoin, Carbamazepine, Clonazepam, Valproic Acid, Gabapentin,
Topiramate, Vigabatrin, Lamotrigine
● Anti-Depressants: Amitriptyline Hydrochloride, Imipramine Hydrochloride, Fluoxetine*, Venlafaxine,
Duloxetine, Sertraline, Citalopram, Escitalopram, Fluvoxamine, Paroxetine
CHAPTER 6
Drugs Acting on Autonomic Nervous System
● Sympathomimetic Agents: Direct Acting: NorEpinephrine*, Epinephrine, Phenylephrine,Dopamine, Terbutaline, Salbutamol (Albuterol), Naphazoline, Tetrahydrozoline. Indirect Acting Agents: Hydroxy Amphetamine, Pseudoephedrine. Agents With Mixed Mechanism: Ephedrine, Metaraminol
● Adrenergic Antagonists: Alpha Adrenergic Blockers: Tolazoline, Phentolamine
● Phenoxybenzamine, Prazosin. Beta Adrenergic
Blockers: Propranolol, Atenolol, Carvedilol
● Cholinergic Drugs and Related Agents: Direct
Acting Agents: Acetylcholine, Carbachol, And Pilocarpine. Cholinesterase Inhibitors: Neostigmine,
Edrophonium Chloride, Tacrine Hydrochloride, Pralidoxime Chloride, Echothiopate Iodide
● Cholinergic Blocking Agents: Atropine Sulphate, Ipratropium Bromide Synthetic Cholinergic Blocking Agents: Tropicamide, Cyclopentolate Hydrochloride, Clidinium Bromide, Dicyclomine Hydrochloride
CHAPTER 7
Drugs Acting on Cardiovascular System
● Anti-Arrhythmic Drugs: Quinidine Sulphate,
Procainamide Hydrochloride, Verapamil, Phenytoin
Sodium, Lidocaine Hydrochloride, Lorcainide Hydrochloride, Amiodarone and Sotalol ● Anti-Hypertensive Agents: Propranolol, Captopril*,
Ramipril, Methyldopate Hydrochloride, Clonidine
Hydrochloride, Hydralazine Hydrochloride, Nifedipine,
● Antianginal Agents: Isosorbide Dinitrate
CHAPTER 8
Diuretics: Acetazolamide, Frusemide*, Bumetanide,
Chlorthalidone, Benzthiazide, Metolazone, Xipamide,
Spironolactone
CHAPTER 9
Hypoglycemic Agents: Insulin and Its Preparations,
Metformin, Glibenclamide, Glimepiride, Pioglitazone,
Repaglinide, Gliflozins, Gliptins
CHAPTER 10
Analgesic And Anti-Inflammatory Agents: Morphine
Analogues, Narcotic Antagonists; Nonsteroidal AntiInflammatory Agents (NSAIDs) – Aspirin, Diclofenac, Ibuprofen, Piroxicam, Celecoxib, Mefenamic Acid,
Paracetamol*, Aceclofenac
CHAPTER 11
Anti-Infective Agents
● Antifungal Agents: Amphotericin-B, Griseofulvin,
Miconazole, Ketoconazole, Itraconazole, Fluconazole, Naftifine Hydrochloride
● Urinary Tract Anti-Infective Agents: Norfloxacin,
Ciprofloxacin, Ofloxacin, Moxifloxacin,
● Anti-Tubercular Agents: INH, Ethambutol, Para
Amino Salicylic Acid, Pyrazinamide, Rifampicin,
Bedaquiline, Delamanid, Pretomanid*
● Antiviral Agents: Amantadine Hydrochloride,
Idoxuridine, Acyclovir, Foscarnet, Zidovudine, Ribavirin, Remdesivir, Favipiravir
● Antimalarials: Quinine Sulphate, Chloroquine Phosphate, Primaquine Phosphate, Mefloquine, Cycloguanil, Pyrimethamine, Artemisinin
● Sulfonamides: Sulfanilamide, Sulfadiazine, Sulfametho xazole, Sulfacetamide, Mafenide Acetate, Cotrimoxazole, Dapsone*
CHAPTER 12
Antibiotics: Penicillin G, Amoxicillin, Cloxacillin, Streptomycin, Tetracyclines: Doxycycline, Minocycline, Macrolides: Erythromycin, Azithromycin, Miscellaneous: Chloramphenicol Clindamycin
CHAPTER 13
Anti-Neoplastic Agents: Cyclophosphamide, Busulfan, Mercaptopurine, Fluorouracil, Methotrexate,
Dactinomycin, Doxorubicin Hydrochloride, Vinblastine
Sulphate, Cisplatin*, Dromostanolone Propionate
Dpharm 1st year subject list:
Pharmaceutics
Pharmaceutical Chemistry
Pharmacognosy
Human Anatomy & Physiology
Social Pharmacy